F. Pacchiano, M. Aggarwal, B. S. Avvaru
Nov 1, 2010
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Influential Citations
211
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Quality indicators
Journal
Chemical communications
Abstract
4-Substituted-ureido benzenesulfonamides showing inhibitory activity against carbonic anhydrase (CA, EC 4.2.1.1) II between 3.3-226 nM were crystallized in complex with the enzyme. Hydrophobic interactions between the scaffold of the inhibitors in different hydrophobic pockets of the enzyme were observed, explaining the diverse inhibitory range of these derivatives.