A. M. Saleh, L. El-Khordagui
May 1, 1985
Citations
0
Influential Citations
128
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
Abstract The term hydrotropic agent was first introduced by Neuberg (1916) to designate anionic organic salts which, at high concentrations, considerably increase the aqueous solubility of poorly soluble solutes. In the present study, an attempt is made to extend the definition of the term to include cationic and non-ionic organic compounds bearing the essential structural features of Neuberg's hydrotropes. The results obtained indicate that model planar cationic compounds such as p-aminobenzoic acid hydrochloride and procaine hydrochloride, and neutral molecules such as resorcinol and pyrogallol confer typical hydrotropic properties.