R. Notari
Sep 1, 1969
Citations
0
Influential Citations
6
Citations
Journal
Journal of pharmaceutical sciences
Abstract
At pH 9.5, 40°, ethyl acetate simultaneously undergoes hydrolysis and hydroxyaminolysis to yield acetic acid and acetohydroxamic acid (N-hydroxyacetamide), respectively. The pseudo first-order rate constants for the overall reaction have been calculated from data based on the colorimetric determination of the hydroxamic acid-iron complex and by the pH-stat method. Yields of both products have been determined. Both O- and N-attack by NH2OH on ethyl acetate has been postulated to explain the observed reaction yields. In the case of the O-attack the resulting O-acetylhydroxylamine is a reactive intermediate which undergoes further hydrolysis and hydroxyaminolysis to yield acetic acid and acetohydroxamic acid, respectively.