G. Hall, T. Le, J. B. Stanford
Aug 1, 1996
Citations
0
Influential Citations
9
Citations
Journal
Pharmaceutica Acta Helvetiae
Abstract
Abstract Ethyl gallate and two related compounds, ethyl 4-hydroxybenzoate and ethyl 3,4-dihydroxybenzoate were evaluated as hydroxyl radical scavengers in a model system using dequalinium chloride and hydrogen peroxide irradiated with simulated sunlight to generate the radicals. All of the compounds showed some hydroxyl radical scavenging properties, with ethyl 3,4-dihydroxybenzoate being the most active under the conditions of test. The molecular implications of these results are considered. The potential radical scavengers were assessed individually for their reaction with photogenerated hydroxyl radicals and the results are discussed. The potential applications of this method for evaluating potential preservatives are also discussed.