J. Berger, B. Tabenkin, R. LeMahieu
May 1, 1969
Citations
0
Influential Citations
16
Citations
Journal
Applied microbiology
Abstract
Cinerone [2-(2'-cis-butenyl)-3-methyl-2-cyclopenten-1-one] is hydroxylated to cinerolone [2-(2'-cis-butenyl)-3-methyl-4-hydroxy-2-cyclopenten-1-one] by a number of streptomycetes, bacteria, and fungi. Aspergillus niger ATCC 9,142 and Streptomyces aureofaciens ATCC 10,762 were found to be the most effective hydroxylators. The optical activity of the product was found to range from [alpha](D) (25) 0 degrees to -8.6 degrees , depending on the organism and conditions of culture. Two additional hydroxylated products of cinerone have been isolated and identified as 2-n-butyl-4-hydroxy-3-methyl-2-cyclopenten-1-one and 2-(2'-cis-butenyl-4'-hydroxy)-3-methyl-2-cyclopenten-1-one, respectively.