E. Appelman, R. Bonnett, B. Mateen
1977
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron
Abstract
Abstract The reaction of hypofluorous acid with aromatic substrates (benzene, p -xylene, naphthalene, and various monosubstituted benzenes) leads to phenolic products. Isomer distribution studies suggest that the reagent has the characteristics of an electrophilic species which is not the OH radical, and which may be regarded as HO δ+ −F δ- . The p -methoxyphenol isolated from the p -deuterioanisole/hypofluorous acid reaction shows a marked NIH effect (77% incorporation of deuterium). The bearing of these results on microsomal hydroxylation is discussed briefly.