Jinyan Dong, Ye-Gao Chen, Hongchuan Song
Feb 1, 2007
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0
Influential Citations
15
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Journal
Chemistry & Biodiversity
Abstract
The ability of the fungus Gliocladium roseum YMF1.00133 to transform the bioactive nigranoic acid (=(24Z)‐9,19‐cyclo‐3,4‐secolanosta‐4(28),24‐diene‐3,26‐dioic acid) was investigated. Three new products from the co‐cultures of nigranoic acid and G. roseum YMF1.00133 were obtained by employing a combination of Sephadex LH‐20 and silica‐gel column chromatography. The major metabolite was identified as 15β‐hydroxynigranoic acid, and the minor metabolites as 6α,15β‐dihydroxynigranoic acid and 7β,15β‐dihydroxynigranoic acid by mass spectrometry and NMR spectroscopy. This is the first report of the biotransformation of the A‐ring‐secocycloartene triterpenoid, nigranoic acid.