Gaetano Riggio, W. Hopff, A. Hofmann
Jun 15, 1983
Citations
0
Influential Citations
17
Citations
Quality indicators
Journal
Helvetica Chimica Acta
Abstract
Hydroxyphenyl-1-methylpyridinium-iodide as Potential Reactivators of Acetylcholinesterase Poisoned with Organophosphorus Compounds. It was our aim to reactivate acetylcholinesterase poisoned with sarin. We synthesized 2-(o-hydroxyphenyl)-1-methylpyridinium-iodide (9), 2-(p-hydroxyphenyl)-1-methylpyridinium-iodide (19) and 4-(o-hydroxyphenyl)-1-methylpyridinium-iodide (14) as potential reactivators. All substances showed moderate toxicity against mice; their reactivity potency in vitro and in vivo was negligible.