Krakoff Ih, Murphy Ml
1968
Citations
0
Influential Citations
24
Citations
Journal
Pediatrics
Abstract
Allopurinol [4-hydroxypyrazolo (3,4-d)-pyrimidine] was used in the treatment or prevention of hyperuricemia in 21 children with various neoplastic diseases in whom there was severe hyperuricemia or in whom it might have been expected as a result of the anti-neoplastic therapy to be employed. Allopurinol was effective in reducing hyperuricemia and in preventing the hazard of uric acid nephropathy in each patient. Previous experience with such patients had been characterized by the frequent occurrence of hyperuricemia and uric acid nephropathy. Allopurinol has produced no toxicity, except for the occasional occurrence of a mild skin rash. It is considered a useful agent in the treatment or prevention of uric acid nephropathy in children with leukemia and lymphoma.