K. Mogilaiah, D. Chowdary
Sep 1, 2002
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0
Influential Citations
2
Citations
Journal
ChemInform
Abstract
2-Aminonicotinaldehyde 1 on condensation with p-chlorophenylacetonitrile 2 affords 2-amino-3-(p-chlorophenyl)-1,8-naphthyridine 3, which is converted into 2-hydrazino-3-(p-chlorophenyl)-1,8-naphthyridinc 4 by the reactionwith hydrazine hydrate and cone. HCl. The hydrazino compound 4 undergo condensation with aromatic aldehydes to give the corresponding 3-(p-chlorophenyl)-1,8-naphthyridin-2-ylhydrazones 5, which on oxidation with iodobenzene diacetate (IBD) in dichloromethane at room temperature furnishes 1-aryl-4-(p-chlorophenyl)-1,2,4-triazolo[4,3-a][1,8]naphthyridines 6. Structural assignments of the products are based on their elemental analyses and spectral (IR, 1 H NMR and MS) data. Compounds 6 synthesized have been screened for their antibacterial activity.