M. Chaubey, S. N. Pandeya
Oct 1, 1989
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Quality indicators
Journal
Farmaco
Abstract
N-[imino(ethyl ethylidine hydrazine)methyl]-N-aryl-2- amino-carbothioamidine hydrochlorides with ethylmethylketothiosemicarbazone in acetone medium at 0-5 degrees C. The carbothioamides were oxidized by H2O2 to 1,2,4-thiodiazolidine derivatives. The 4-Cl derivative in both the series was the most active hypoglycaemic agent. The compounds lowered mean blood sugar levels (MBSL) by 38.81% (compound 2, Table II) and 15.19% (compound 2, Table III) respectively after 24 hours of drug treatment. The compounds also showed antidiabetic activity in alloxan diabetic rats.