A. Milbert, R. Wiley
Mar 1, 1978
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
2-Pentadecyl-4-hydroxymethyl-1,3-dioxolane monosodium phosphate (1) has been shown to exhibit bradycardia and hypotension in rats. It is, however, unstable in aqueous solution. In this study, the stable analogues of 1, 2-pentadecyl-5-hydroxymethyltetrahydrofuran monosodium phosphate (7), and 1-hydroxymethyl-3-pentadecylcyclopentane monosodium phosphate (17) were prepared. These substances exhibited cardiovascular effects similar both qualitively and quantitatively to those elicited by 1 and were stable in solution for about 24 and at least 72 h, respectively.