Alan A. Wilson, R. Dannals, H. Ravert
1986
Citations
0
Influential Citations
10
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The radioiodination of 4-trimethylsilylbenzyl bromide in acetic acid with no carrier added I-125 and I-123 iodide ion and N-chlorosuccinimide (NCS) is a rapid, high yielding process which produces high specific activity 4-[I-125 or I-123]iodobenzyl bromide. This radiolabelled alkylating agent has been efficiently reacted with N,N-dimethylaniline and triphenylphosphine to generate radiolabelled quaternary ammonium and phosphonium salts, and should be useful for labelling other biologically important molecules which possess suitable nucleophilic functional groups.