K. Midha, J. Cooper, A. By
Mar 1, 1977
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Drug metabolism and disposition: the biological fate of chemicals
Abstract
3-O-Methyl-alpha-methyldopamine has been separated by gas-liquid chromatography (GC) as a metabolite of MDA in the urine of dog and monkey. The metabolite was identified as its mono- and di-trifluoroacetyl derivatives by comparison of their GC and GC-mass spectral properties with those of synthetic compounds. The amount of metabolite increased on hydrolyzing the urine from dosed dogs and monkeys with a preparation containing beta-glucuronidase and sulfatase.