Taisaku Tanaka, Tsuyoshi Muto, H. Maruoka
Jun 15, 2007
Citations
1
Influential Citations
20
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A novel series of 6-substituted 4-sulfonyl-1,4-diazepane-2,5-diones were designed, synthesized and evaluated as human chymase inhibitors. Structure-activity relationship studies led to the identification of a potent inhibitor, (6S)-6-(5-chloro-2-methoxybenzyl)-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepane-2,5-dione, with an IC(50) of 0.027 microM.