R. F. Dietrich, R. W. Reiser, B. Stieglitz
Feb 1, 1995
Citations
0
Influential Citations
9
Citations
Journal
Journal of Agricultural and Food Chemistry
Abstract
Triflusulfuron methyl (methyl 2-[[[[[4-(dimethylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino]carbonyl]amino]sulfonyl]-3-methylbenzoate) is a new selective low use rate sulfonylurea herbicide for the control of many broad-leaved weeds and grasses in sugar beets. Our studies show the compound undergoes rapid microbial metabolism using Streptomyces griseolus and that a mixture of similar metabolites is excreted by triflusulfuron methyl-dosed rats. Nine intact sulfonylurea metabolites were tentatively identified in microbial studies, and five of these were later identified in urine or feces of rats dosed with radiolabeled triflusulfuron methyl. Metabolic reactions include alkyl and/or aryl oxidation, N-dealkylation, and ester hydrolysis. All identifications were made using liquid chromatography/mass spectrometry (LC/MS) with fast atom bombardment (FAB) ionization. FAB mass spectra gave strong protonated molecular ions and structurally useful fragment ions of these extremely thermally labile metabolites