Mancheng Tang, Yi Zou, Danielle A. Yee
Jun 27, 2018
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Influential Citations
20
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Journal
AIChE journal. American Institute of Chemical Engineers
Abstract
Pyranonigrins are a family of antioxidative compounds that are reported to be secondary metabolites produced by Aspergillus niger, all featuring a unique pyrano[2,3-c]pyrrole bicyclic skeleton which is rarely found in nature.1–4 Of this family, pyranonigrin A (Figure 1) was shown to have the activity as a 1,1-diphenyl-2-picrylhydrazyl radical scavenging reagent.5 Previously, a biosynthetic gene cluster from A. niger ATCC 1015 was transcriptionally activated by overexpressing the pathway specific transcriptional regulator, leading to the identification of a new member of this family, pyranonigrin E.6 Though the biosynthetic pathway of pyranonigrin E was well-established based on gene knockout studies6,7, the biosynthesis of pyranonigrin A remains unclear. Recent isotope labeling studies showed that the backbone of pyranonigrin A is derived from four units of acetate and one unit of glycine8, suggesting a polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid enzyme may be involved.