J. C. Cleveland, S. Litvak, J. W. Cole
Apr 1, 1967
Citations
0
Influential Citations
45
Citations
Quality indicators
Journal
Cancer research
Abstract
Wistar rats were used in the identification of the route of action in the induction of intestinal neoplasia by the carcinogen 3:2′-dimethyl-4-aminobiphenyl. By operative manipulation, segments of the rat colon were defunctionalized and fecal contact with intestinal mucosa was minimized. Rats were given the carcinogen in a convenient dosage schedule, and neoplasia was induced. Interpretation of these experiments suggests that the chemical is absorbed from the injection site; modified, probably in the liver; excreted into the bile; and neoplasia induced by direct contact of feces with the intestinal mucosal cell.