T. Sastry
2013
Citations
1
Influential Citations
5
Citations
Journal
Asian Journal of Chemistry
Abstract
Prasugrel hydrochloride is designated chemically as 5[1(RS)-2-cyclopropyl-1-(2-fluorophenyl)-2-oxyethyl]-4,5,6,7tetrahydrothieno[3,2-c]pyridine-2-yl acetate hydrochloride (1). The literature synthesis (Scheme-I) involves condensation of 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone (2) with 5,6,7,7a-tetrahydrothieno[3,2-c]pyridine -2(4H)-one hydrochloride (3) in the presence of base and acetonitrile gives 5(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7atetrahydrothieno[3,2-c]pyridin-2(4H)-one (4), on treatment with acetic anhydride in presence of base and DMF affords prasugrel base (5) which on reaction with hydrochloric acid in presence of acetone gives prasugrel hydrochloride (1).