J. Ontoria, J. I. Martín Hernando, Savina Malancona
Aug 1, 2006
Citations
0
Influential Citations
40
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Thieno[3,2-b]pyrroles are a novel class of allosteric inhibitors of HCV NS5B RNA-dependent RNA polymerase which show potent affinity for the NS5B enzyme. Introduction of a polar substituent in the position N1 led to a compound that efficiently blocks subgenomic HCV RNA replication in HUH-7 cells with an EC50 of 2.9 microM.