Yang He, Meng Wu, Yang-guang Liu
Sep 30, 2016
Citations
0
Influential Citations
4
Citations
Journal
ACS medicinal chemistry letters
Abstract
A compound, triptophenolide, derived from Tripterygium wilfordii was identified as an antiandrogen. Triptophenolide inhibits the activity of both wild-type and F876L mutant androgen receptors. Triptophenolide exhibits its antiandrogenic activity through competitive binding with androgen in the hormone-binding pocket, decreasing the expression of androgen receptor, and reducing the nuclear translocation of androgen receptor.