Man-Ho Choi, B. Jung, B. Chung
Jan 1, 1999
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
The metabolism of clemastine, 2‐{2‐[1‐(4‐chlorophenyl)‐1‐phenylethoxy]ethyl}‐1‐methylpyrrolidine, has been studied in three adult male volunteers after a single oral dose of 20 mg as the fumarate. After enzymatic hydrolysis solvent extracts of urine were derivatized with N‐methyl‐N‐trimethylsilyltrifluoroacetamide‐ammonium iodide and analysed by gas chromatography‐mass spectrometry. The structures of metabolites were determined on the basis of electron impact and chemical ionization mass spectra and the identities of some (e.g. carbinol, 4‐chlorobenzophenone and 4‐chlorophenylstyrene) were confirmed by use of authentic standards.