P. C. Srivastava, F. F. Knapp, A. P. Callahan
Oct 1, 1990
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The phosphonium compounds, [(Z) and (Z/E)-(1-bromo-1-penten-5-yl)]triphenylphosphonium iodides (yield, 65–70%) and the corresponding bromine-82-labeled analogues have been prepared as potential myocardial imaging agents. The 2/1 isomer composition of the Z/E mixture has been confirmed by single crystal X-ray analysis. The radiobrominated (Z)-isomer and (Z/E)-mixture both show high heart uptake and high heart/blood ratios in rats. These data suggest that the bromine-75 and bromine-76-labeled agents could be good candidates for myocardial imaging using positron emission computed tomography.