F. Stauffer, S. Maira, P. Furet
Feb 1, 2008
Citations
0
Influential Citations
81
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Imidazo[4,5-c]quinoline derivatives have been discovered and developed as potent and effective modulators of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) pathway to lead to clinical development candidates. The SAR data of representative examples of this compound class and their biological profiling in cellular and in vivo settings are presented and discussed.