Upender Velaparthi, Peiying Liu, Balu N. Balasubramanian
Jun 1, 2007
Citations
0
Influential Citations
38
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.