J. Heeres, L. Backx, J. Mostmans
Aug 1, 1979
Citations
2
Influential Citations
296
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
The preparation and antifungal properties of cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine (I) are described. Ketoconazole has, at low oral doses, a high in vivi activity against vaginal candidosis in rats and against cutaneous candidosis in guinea pigs.