T. Sugimoto, K. Shibata, S. Matsuura
Mar 1, 1979
Citations
0
Influential Citations
1
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Several imidazo[1,2-c]pteridines with a functional group such as amino, alkylamino, alkoxyl, or hydroxyl group at the 6-position were synthesized by a nucleophilic replacement of 6-methylthioimidazo[1,2-c]pteridine with an appropriate nucleophile. The key intermediate methylthio compound was synthesized by condensation of 4-amino-2-methylthiopteridine with chloroacetaldehyde. Similarly, 4-amino-6,7-dimethyl-2-methylthiopteridine and chloroacetaldehyde gave 2,3-dimethyl-6-methylthioimidazo[1,2-c]pteridine, which was also used as a precursor to synthesize several imidazopteridines analogous to above.