A. Tagliabue, G. Allesandri, N. Polentarutti
Apr 1, 1978
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
European journal of cancer
Abstract
Abstract A preliminary characterization of 3-(p-chlorophenyl)-2,3-dihydro-3-hydroxythiazolo [3,2-α]-benzimidazole-2-acetic acid was conducted in mice employing tumorous and non-tumorous systems. Single doses of this chemical markedly increased the primary and secondary anti-SRBC response after optimal immunization and raised the GvH-inducing capacity of splenocytes whereas no effects were seen on the response to a T-independent antigen. Immunostimulatory doses of the drug did not modify colloidal carbon clearance, macrophage non-specific cytotoxicity towards lymphoma cells or K cell activity in the spleen. Single injections with this agent increased survival in L 1210Ha leukemia-bearing mice when administered in conjunction with irradiated tumor cells and increased anti-leukemia resistance to subsequent tumor challenges in animals primed with inactivated leukemia cells. Single drug doses 1 day after tumor transplantation exerted also a potent antimetastatic effect in the Lewis lung carcinoma system.