Sarkar Nn
1982
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Quality indicators
Journal
Health and population; perspectives and issues
Abstract
A single silastic implant containing 40 mg norethindrone acetate (NETA) is one of the long-acting contraceptive devices for women. The in vivo release rate of NETA from this device is within the range of 128 to 188 mg/day in women rats and rabbits. However the serum norethindrone (NET) concentration has been found to be around 1 ng/ml in women rabbits and rhesus monkeys after insertion of an implant for 6 to 8 months. The contraceptive efficacy of this device is high. The pregnancy rate is only 2.2 to 3.9/100 women at the end of 3 months after insertion of the implant. There is incidence of disturbance in the normal hormonal profile in women indicating the suppression of ovulation in some cases. The cycle abnormalities decrease with the prolongation of treatment. No metalic disorders have been observed in women in various clinical trials with this device. The single silastic implant releasing NETA appears to be acceptable to women for the control of conception. (authors modified) (summaries in ENG HIN)