K. Shimokawa, Ryoka Miwa, Kaoru Yamada
Feb 4, 2009
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Influential Citations
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Journal
Organic & biomolecular chemistry
Abstract
Key relationships between the intramolecular H-bond-derived backbone conformation and the bioactivity of the novel fat-accumulation inhibitor (-)-ternatin are examined by analyses of the NMR spectroscopic data and CD spectra of designed analogues. The results reveal that the beta-turn structure of (-)-ternatin is responsible for its potent fat-accumulation inhibitory effect against 3T3-L1 murine adipocytes.