K. Patel, D. Patel
Apr 28, 2022
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Journal
The Natural Products Journal
Abstract
Phytochemicals are an important class of natural compounds present in vegetables, herbs, fruits, and seeds. Phytochemicals have been used in the medicine for the treatment of human disorders in the form of drugs, medicine and Nutraceuticals. Flavonoid class secondary metabolites were found to be present in medicinal plants and some food material derived from plants. Flavonoid class phytochemicals have health beneficial aspects and numerous pharmacological activities in the medicine. Psoralea corylifolia have been widely used in the medicine for the treatment of skin diseases, including vitiligo, alopecia areata, leukoderma, and psoriasis. More than 90 different types of phytocompounds have been separated and isolated from Psoralea corylifolia. Bavachinin is a flavonoid class phytochemical, found to be present in the seeds of Psoralea corylifolia. Bavachinin possess anti-bacterial, anti-oxidative, anti-inflammatory, α-glucosidase and nitric oxide inhibitory potential. Methods: Scientific data of bavachinin have been collected from different literature databases such as Google, Google Scholar, PubMed, Science Direct and Scopus in the present work and analyzed to know the biological importance of bavachinin. Scientific research data of bavachinin have been collected in the present work for their medicinal importance, pharmacological activities and analytical aspects. Further, all the collected scientific data have been separated into different sub-sections i.e. medicinal importance, pharmacological activities and analytical aspects of bavachinin. Detailed pharmacological activity data of bavachinin have been analyzed in the present work to know the therapeutic potential of bavachinin in the medicine. Analytical data of bavachinin have been collected and analyzed in the present work to know the biological importance of bavachinin in the modern medicine for the standardization of Psoralea corylifolia. Results: Literature data analysis of different scientific research work revealed the biological importance of flavonoids in the medicine. Flavonoid class phytochemicals have had anti-inflammatory, anti-oxidant, anti-viral, anti-cancer and anti-ageing properties in the medicine. Scientific data analysis revealed the effectiveness of bavachinin in cancer, blood glucose, Alzheimer's disease, Parkinson's disease, inflammation, immune system, T cell differentiation, oxidative damage and enzymes. However, therapeutic efficacy, metabolism, biotransformation, pharmaceutical product development and pharmacokinetic parameters of bavachinin have been also discussed in the present work. Analytical data signified the importance of modern analytical tools for the separation, isolation and identification of bavachinin from various plants. Conclusion: Scientific data analysis of different research work revealed the biological importance and therapeutic benefit of bavachinin in the medicine.