Fan Wang, Xiao‐Ying Xu, Fei-ying Wang
Oct 28, 2013
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0
Influential Citations
10
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Journal
Organic Process Research & Development
Abstract
An improved, practical, economical and efficient process for the production of (2S,4S)-2-amino-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoic acid, a key intermediate of the new potent renin inhibitor of aliskiren, in a total yield over 30% is described. This process avoids expensive reagents and chromatographic purifications, and is easily scaled up in industry.