Itsuo Murakami, S. Mitsutake, N. Kobayashi
Jan 23, 2013
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Influential Citations
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Journal
Bioscience, Biotechnology, and Biochemistry
Abstract
We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in cells. PPARγ is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes.