S. Matsumoto, T. Rigley, J. Reems
Jan 1, 2003
Citations
1
Influential Citations
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Journal
American Journal of Transplantation
Abstract
We tested whether two‐layer method (TLM) pancreas preservation and trypsin inhibition (Pefabloc) during processing allows longer preservation while retaining or improving viable islet recovery. Non‐marginal primate (Macaca nemestrina) and marginal human (ischemic or preservation‐injured) pancreata were processed with a research‐oriented pan technique (Seattle method). Organs were processed upon arrival (± Pefabloc), or after TLM or University of Wisconsin solution (UW) preservation (+ Pefabloc). Islet yield, viability, and function were assessed.