M. Ikeda, M. Kawase, M. Hiramatsu
Jul 11, 1980
Citations
0
Influential Citations
23
Citations
Journal
Journal of chromatography
Abstract
Diclofenac was converted into either its methyl or ethyl ester in methanol or ethanol containing 0.1% or 0.5% sulfuric acid, respectively. The ester was extracted and subjected to gas--liquid chromatography with electron-capture detection. The esterification resulted in an increased sensitivity of the gas chromatographic detection, three times better than that previously reported for the formation of indolone ring in trifluoroethanol containing 0.5% sulfuric acid.