Zhou Zhuo-qiang
2009
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Guangzhou Chemical Industry
Abstract
Ethyl 2-amino-thiazole-4-carboxylate was synthesized with thiourea and ethyl bromopyruvate by solvent-free.Then it was reacted with DMSO and sodium nitrite by diazotization in high temperature to form ethyl 2-bromothiazole-4-carboxylate.Finally,the 2-bromo-thiazole-4-carboxy acid was synthesized by ethyl 2-bromothiazole-4-carboxylate through saponification in potash-methanol solvent.The compounds were determined by means of melting point measurement,IR,MS(ESI),1H-NMR.The result showed exact structure and purity.