M. Micklatcher
Nov 1, 1999
Citations
0
Influential Citations
5
Citations
Journal
Synthesis
Abstract
: An improved method for the synthesis of 3-fluorosalicyl-ic acid is described. A positional protective group strategy allows formylation selectively at the ortho position of 4-bromo-2-fluo-rophenol. Oxidation of the resulting salicylaldehyde to the salicylic acid, followed by debromination, affords 3-fluorosalicylic acid. The method has also been applied to the synthesis of 3-(trifluorometh-yl)salicylic acid.