Zheng Min
2013
Citations
0
Influential Citations
0
Citations
Journal
Journal of Nanchang University
Abstract
Objective To improve and optimize the synthetic method of prasugrel intermediate 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone.Methods A Grignard reagent,prepared by 2-fluorobenzyl bromide,was added into cyclopropanecarbonitrile to produce cyclopropyl 2-fluorobenzyl ketone,which was then illuminated with 1,3-dibromo-5,5-dimethylhydantoin for 4 hours.The resulting product was evidenced to be 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone.Results Methylene chloride was used as a solvent and benzoyl peroxide as a reaction accelerator.The content of the obtained product was 96%.The productivity was 83.9%.Conclusion The improved synthetic method is reasonable and feasible for the industrial production of 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone.