S. Lan-xiang
2009
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Journal
Journal of Hebei University of Science and Technology
Abstract
Hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one was prepared by aromatization of hexahydro-1-methyl-3-(3-oxocyclohexen-1-yl)-2H-azepin-2-one using Br2 reagent in 90% yield at room temperature.Meptazinol was obtained by reduction of 3-ethylhexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one using RED-Al as reducing agent in 70% yield.The present approach offers several advantages such as shorter reaction time,high yields,less power consumption,and mild reaction condition,thus suitable for large-scale preparation.