R. Zhao, Bei Wang, Hongui Wu
Dec 20, 2009
Citations
0
Influential Citations
2
Citations
Journal
Arkivoc
Abstract
A new efficient method was developed for the preparation of 2-methyl-1-(2-morpholinoethyl)- 1H-indole-3-carboxylic acid. The new method involves N-alkylation of 7-methoxy-2- methylindole with 4-(2-chloroethyl)morpholine hydrochloride followed by trichloroacetylation and hydrolysis in 3 steps and 88% overall yield.