N. D. Shashikumar, G. Krishnamurthy, K. SundaraRajRao
May 25, 2010
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0
Influential Citations
5
Citations
Journal
Organic Process Research & Development
Abstract
An improved process has been developed for the synthesis of 5-bromo-3-(1-methylpiperidin-4-yl)-1H-indole, a key intermediate of naratriptan hydrochloride, which is used as a drug for migraine. A novel one-pot synthetic procedure using triethyl silane was developed for scale-up.