L. Meng
2010
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Journal
Chinese Journal of Applied Chemistry
Abstract
2-Mercapto-5-methoxyimidazo[4,5-b]pyridine was obtained with 2,6-dichloropyridine as the starting material in five steps,including methoxylation,nitration,amination,reduction and cyclization.The overall yield of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine was up to 45.7%.The differences between reaction conditions and yields of nitration of 2-chloro-6-methoxypyridine and 2,6-dichloropyridine were discussed,the effects of the amounts of hydrazine hydrate and the amounts of sodium hydroxide on the yield of the target product were also discussed.The structure of the target product was identified by 1H NMR,MS and IR.