Josep Rayo, L. Muñoz, G. Rosell
Sep 1, 2010
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Journal
Synthesis
Abstract
A highly efficient and environmentally friendly method for the synthesis of 3-alkoxy-1,1,1-trifluoropropan-2-ols is present- ed. The approach involves ring-opening reaction of 1,1,1-trifluoro- 2,3-epoxypropane with structurally different long-chain alcohols under microwave irradiation at room temperature in the absence of solvent. These chemicals are precursors of the corresponding tri- fluoromethyl ketones, potent inhibitors of human and murine liver microsomes and porcine liver esterase.