C. Spiteri, Pallavi Sharma, Fengzhi Zhang
Feb 9, 2010
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Influential Citations
46
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Journal
Chemical communications
Abstract
An efficient synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reaction partners mediated by TBAF. Reactions are complete within 30 s, giving the target products in good to excellent yield.