Rao Er-chang
2006
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0
Influential Citations
1
Citations
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To improve the synthetic process of 1H-indazole-3-carboxylic acid.Methods The reaction of benzaldehyde phenylhydrazone with oxalyl chloride gave N-benzylideneamino-N-phenyl oxamoyl chloride,and then the product was treated with AlCl_3 to afford the key intermediate N-benzylideneamino-isatin which was converted into 1H-indazole-3-carboxylic acid by refluxing with hydrochloric acid.Results and conclusion This improved synthesis with an overall yield of 55.3% shows the advantages of lower cost of starting materials and reagents,mild reaction condition and simple operation,it is suitable for industrial manufacture.