S. Hongbin
2009
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0
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Journal
Journal of China Pharmaceutical University
Abstract
Aim:To improve the synthesis for 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol.Methods:Dehydration of D-mannitol,followed by a reaction sequence of selective protection,benzylation,deprotection,tritylation,benzylation and removal of the trityl group,afforded the title compound.Results:Based on the improvement of the reported synthetic route,2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol was synthesized in seven steps from D-mannitol with a total yield of 8.3%.Conclusion:This new method features mild reaction conditions and facile work-up.