G. Makara, K. Klubek, W. Anderson
May 1, 1996
Citations
0
Influential Citations
11
Citations
Journal
Synthetic Communications
Abstract
Abstract An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give phthalide 3 in 55% overall yield.