T. Ashton, P. Scammells
Jul 15, 2005
Citations
1
Influential Citations
26
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Synthesis of 5'-fluoro-5'-deoxyadenosine (5'-FDA) and structurally similar compounds is generally a poor yielding process. This is attributed to the instability of the selected synthetic intermediates. Herein, we report a general synthesis of 5'-fluoro-5'-deoxy-N6-substituted adenosines including a high yielding access to 5'-FDA.