Ji Ya-fei
2011
Citations
0
Influential Citations
3
Citations
Journal
Chemistry World
Abstract
Benzophenone,as a starting material,went through a series of reactions,such as Darzens,methanolysis and hydrolysis to give 2-hydroxy-3-methoxy-3,3-diphenylpropionic acid(5).The latter reacted with L-proline methyl ester hydrochloride(7) and a diasterotropic resolution was carried out to provide the key intermediate(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid(6).Finally,the target product ambrisentan(1) was obtained from 2-methylsulfonyl-4,6-dimethylpyrimidine(8) and 6 via a nucleophilic substitution with an overall yield of 26.5%.