Dai Jun
2008
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Journal
Journal of Anyang Normal University
Abstract
To improve the sysnthesis of amtolmetin guacil,amtolmetin guacil was synthesized using Tolmetin sodium 2 as the starting material,and with isobuty chloroformate、glycine reacted to get midbody Tolmetin glycinamide 3,then with isobuty chloroformate、guaiacol reacted to get amtolmetin guacil 1,meanwhile researching method of refinding means of 1.Finally,reacting condition of improved technology was moderate,simplicity of oprator,improving quality of sighting vane 1 and the overall yied was 65%,having benefit of large-scale industrialization production.